This is a pdf file of an unedited manuscript that has been. Influence of infarct zone viability on left ventricular remodeling after percutaneous coronary intervention versus optimal medical therapy alone. A randomized trial of a bioabsorbable polymerbased. Coronary intervention for persistent occlusion after. Occluded artery trial oat oat the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The new england journal of medicine 2396 n engl j med 355. The occluded artery trial oat demonstrated no difference in clinical outcomes over five years between patients randomized to percutaneous coronary intervention pci versus optimal medical therapy alone med in stable patients with an occluded infarct related artery ira 328 days postmi. We report the results of the occluded artery trial oat, which tested the hypothesis that a strategy of routine pci for total occlusion of the infarctrelated artery 3 to 28 days after acute. In the occluded artery trial oat, percutaneous coronary intervention pci of an infarctrelated artery on days 3 to 28 after acute myocardial infarction was of no benefit compared to medical. The occluded artery trial oat showed no difference in outcomes between. Procedural success, hazard, and outcomes over 5 years. In patients with peripheral artery disease who had undergone lowerextremity revascularization, rivaroxaban at a dose of 2. Occluded artery trial oat study protocol november 1, 2000 pilot phase versions november 28, 1997 february 2, 1998 june 1, 1998 main trial june 1, 1999. Where does the occluded artery trial leave the late open artery.
The occluded artery trial oat viability ancillary study oatnuc. A randomized trial of a bioabsorbable polymerbased metallic des vs. Chronic total coronary occlusions and the occluded artery trial. Chronic total coronary occlusions and the occluded artery. Patients with stroke due to vertebral and basilar artery stenosis have an. The occluded artery trial oat viability ancillary study. The coronary intervention for persistent occlusion after myocardial infarction occluded artery trial, oat study evaluated treatment of 2166 highrisk, but otherwise stable survivors of a myocardial infarction and persistent total occlusion of the infarctrelated coronary artery high risk criteria included an ejection fraction of artery trial oat viability ancillary study oatnuc. Oat occluded artery trial 2007 clinical cardiology. Between one and three million americans suffer from asymptomatic carotid artery stenosis acas, a key stroke risk due to the accumulation of plaque. Given the paucity of data to guide management, the occluded artery trial oat enrolled patients with recent mi 328 days prior to test the. Longterm effects of percutaneous coronary intervention of the. Cea for symptomatic patients with 70% to 99% carotid stenosis or selected patients with 50% to 69%. Percutaneous coronary intervention in the occluded artery trial. Listing a study does not mean it has been evaluated by the u.
Pdf on jun 1, 2008, gerald s werner and others published chronic total coronary occlusions and the occluded artery trial. Pdf percutaneous coronary intervention in the occluded. The nascet 1,2 and ecst 4 trials addressed the use of. The goal of the trial was to evaluate percutaneous coronary intervention pci compared with medical therapy among stable, highrisk patients with persistent total occlusion of the infarctrelated artery postmyocardial infarction mi. Occluded artery trial american college of cardiology. Design and methodology of the occluded artery trial oat article in american heart journal 1504. Design and methodology of the occluded artery trial oat. Occluded artery trial oat randomized comparative effectiveness trial of pci and medical therapy only post mi. Basic and clinical research elucidated the concept that an epicardial coronary artery occlusion leads to.670 1470 50 1345 1092 789 79 435 818 154 809 1308 741 9 1150 583 722 1407 1364 1535 1153 889 328 1464 542 140 1172 1272 1026 666 36 775 1290 1493 385 309 956 1071 1294 151 841